10 Signs You Might Be Pregnant

1. No touching is the ‘breast’ policy…Your man has been warned off your lady bumps. Find out more about sleep apnea cures from Positive Health Wellness – https://www.positivehealthwellness.com/ Not just warned…you’re thinking about committing homicide every time he does the ‘accidental brush.’ Why? Because they’re sore, and I’m not talking a little uncomfortable, they are tenderer than a Thanksgiving turkey. Pregnant boobs are swollen, full, even ‘hard’ feeling, and very painful. And your man had best find a new hobby to play with.

2. Just call them the ‘Areola Twins’… so your boobs are like twin domes of evil. Well, now they’re watching you with their big, dark eyes. You’re not seeing things, your areolas just became darker seemingly overnight, and increased in size. Those bumps around your areola are probably enlarged too. It’s your hormones ladies, and this is perfectly normal if not a bit, well, disconcerting. Welcome to pregnancy breasts at their finest. Now just you wait until they grow as big as watermelons and can no longer be contained by Victoria Secret. You’re headed for tent-sized maternity bras. Yikes.

3. Holy spotty underwear, Batman! If you discover some light to medium pink splotching in your undies earlier than you expected Aunt Flo to visit, it’s nothing to worry about. A spray of stain remover and you’re as good as new. When the embryo (your embryo) implants in the uterus around five to ten days after conception, you could experience ‘implantation bleeding.’ It’s icky, but not life threatening.

4. You just gotta, gotta, gotta go…the need to pee over and over and over again, is a good indication you’re knocked up, sunshine. It’s actually one of the earliest signs. Oh very well, I’ll excuse you from reading this article to go again…don’t forget to grab a roll of toilet paper…

5. You’re asleep on your feet! You tell your man you’re off to bed before eight o’clock, and if he thinks it’s a hint you want sex, boy is he going to be disappointed. You are totally and utterly exhausted. All the time. 24/7. Extreme fatigue is a neon sign you’re pregnant. Your body is surging with hormones and working overtime to make your baby. If you can, sleep. Sleep the whole nine months. Because when your baby is here, you’ll forget what that is.

6. “You make me sick!” I mean literally, not figuratively…well, maybe both. If you’re nauseas, and the mere action of brushing your teeth makes you hurl into the sink, chances are you’re ‘you know what’…

7. Your sniffer is sensitive…if you can smell with the efficiency of a blood hound, you’re probably pregnant. Sensitivity to odors is one of the first signs, probably because of increasing estrogen levels. Unfortunately, most things you smell won’t inspire happiness and harmony. Frying hamburger meat will most likely throw you into a violent vomit fest (see above.)

8. You’re stomach could make a living at Seaworld…you are bloated beyond belief. If someone makes the mistake of pressing against your abdomen, the effect could be likened to a five foot tall whoopee cushion. Another early sign of pregnancy. You might want to invest in some stretchy pants with an elastic waistband.

9. You’re late, you’re late, for a very important date! So you’re pretty sure you should have started your period already…so where is it? If you’re as confused as Alice down a rabbit hole, and your usual date with a maxi pad has been cancelled, it’s time to face the facts. You’re doubtless in the family way.

10. There’s a line in both test windows…you’ve pee-ed on the stick and stared at the pregnancy test anxiously for three minutes, with your partner pacing nervously in the background. The result is…hang on, read the instructions again…YOU’RE PREGNANT! At this point you can be pretty sure-at least 99% sure anyway. Make an appointment with your general practitioner, and a simple urine test will confirm it.

Fair Gene Solutions

Patients faced with a genetic disease are asking clinicians. In many instances there is a known underlying reason for a disorder afflicting a family. Medical Information UK the knowledge of a specific disease-causative mutation(s) allows not only better disease prognosis but also allows families to ensure that the next generation of kids will be free of disease.

Single-gene disorders are individually rare, but with more than 3500 Mendelian disorders, for half of which disease gene has not yet been uncovered, enthrall an enormous impact on the well-being of over 500,000 children in Canada.

Genetics in conjunction with pre-implantation genetic diagnostics (PDG), can save life long suffering from a genetic disease, but only if there is a clear understanding of disease susceptibility. Knowing individual’s genomic profile allow us to better prepare or to avoid the negative impacts they might have on health and lifespan of the individual an his/her descendants.

Until recently we did not know how to identify rapidly the underlying mutations within our genome. The genetic mapping process required analysis of multiple affected families with similar disease manifestations, but in many cases the final result was inconclusive as resolution of this analysis was too low.

Recently genetic technologies have developed at neck braking speed creating a huge gap in understanding of the benefits and limitations for general population as well as the majority of medical professionals. In the short years since the first Next Generation Sequencing (NGS) became available it has dramatically accelerated multiple areas of genomics research, uncovering genetic defects underlying inherited disorders.

Today, the number of known disease causing mutations exceeds 100,000 in more than 3700 different genes. However, this figure represents only a small fraction of the clinically relevant genetic variants in the human genome – recent studies have estimated that about 40% of disease-causing mutations are so rare that they occur only in one family.

NGS, and specifically exome sequencing, brings new ways of assessing genetic disorders: protein-coding genes constitute only approximately 1% of the human genome but harbor about 85% of the disease-causing mutations. Therefore, exome analysis allows capturing most Mendelian disorders that are caused by “coding mutations” or splice-site mutations.

Our current challenge is the ability to identify a pathogenic variant among the many thousands of new variants detected in each individual. With the development of bioinformatics analysis tools and the availability and rapidly decreasing cost exome sequencing offer new opportunities for identifying new causes of genetic disease.

Several initiatives such as the Canadian Pediatric Genetic Disorders Sequencing (CPGDS) Consortium that evolved in to larger Finding of Rare Disease Genes (FORGE Canada), and Rare Disease Consortium for Autosomal Loci (RaDiCAL) aim to characterize Mendelian disorders through exome sequencing.

This technology already has lead to remarkable life-saving discoveries: Nicholas Volker is the first boy saved by sequencing technology. Since birth he was afflicted with “mysterious” severe inflammatory bowel disease due to a mutation in XIAP – one of immune response genes, so doctors figured our that a bone morrow transplant will cure his disease. Another remarkable example is Shelby’s story who was a severely disabled by an autism-like disorder to ditch a wheelchair after scientists where able to find appropriate medication based on her genetic profile.

Pioneering work is being done at Children’s Mercy Hospitals and Clinics in Kansas City where physicians sequenced genomes of 40 sick babies in the Neonatal Intensive Care Unit within 50 hours. “Up to one third of babies admitted to a NICU in the U.S. have genetic diseases,” said Stephen Kingsmore, M.B. Ch.B., D.Sc., FRCPath, Director of the Center for Pediatric Genomic Medicine at Children’s Mercy. “By obtaining an interpreted genome in about two days, physicians can make practical use of diagnostic results to tailor treatments to individual infants and children.”

Ironically, the power of exome sequencing is not yet harnessed for analysis of fertility and family planning. Understanding of inherited genetic risks helps to avoid many preventable tragedies such as children’s death due to heart failure as majority of these conditions are congenital – i.e. have underlying genetic cause.

Family is the essential unit of health from multiple perspective and members share the same environmental risk factors such as dietary habits, as well as emotional and genetic connections that together impact on happiness and longevity. Therefore, we advocate proactive family planning starting with genetic analysis of prospective parents.

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